– A high zinc to copper ratio may indicate a high histamine response, so very small amounts of copper may be needed. Copper helps raise DAO levels and helps break down histamine. The balance of zinc to copper is so tricky (as discussed on other posts), however using a hair mineral test can help guide what you need. Copper supplements vary in bioavailability so using a high quality copper is so important.
– Calcium isn’t always mentioned when trying to help reduce histamine. I personally find this is a key treatment. Calcium pulls histamine into the blood for elimination. In order to be properly absorbed, calcium needs other nutrients such as magnesium, boron and vitamin K2.
– Magnesium is an important cofactor in the production of DAO and magnesium deficiency may result in decreased DAO activity and excess histamine levels. Again dosage and using the right supplement/s so they can be absorbed is important. I sometimes use a combination of different forms of magnesium. There are also other nutrients that need to be in place to help absorb magnesium.
– Vitamin B6 and Vitamin C, are other important DAO cofactors. But again correct dosage, too much vitamin C can cause oxalate problems and too much B6 can cause nerve problems.
– Low stomach acid and poor liver function are also huge underlying factors I look at when helping clients with histamine issues.
–Probiotics: Bifidobacterium Infantis can be useful. Lactobacillus Plantarum and Lactobacillus Rhamnosus are also worth looking into. More on these another day!
–Binders may be useful for some, such as Toxaprevent or TRS.